The Head of the Laboratory – Varyvonchyk Denys Vitaliyovych, Doctor of Medical Sciences, Senior Researcher, Honored Doctor of Ukraine, R. E. Kavetsky Prize Laureate of the National Academy of Sciences of Ukraine
The first research on the problem of occupational cancer in the "Institute of Occupational Health named after Yu. I. Kundiev of the NAMS" began in the 1950s (Yu. I. Kundiev, O. P. Krasnyuk, M. O. Ershova, and others).
In the 90 years of the 20th century, complex medico-biological, hygienic and clinical researches on occupational cancer among welders, workers of metallurgical and machine-building plants were carried out in the Institute (Yu. I. Kundiyev, O.P. Krasnyuk, L.M. Gorban, T.K. Kucheruk, I.P. Lubyanova, O.V. Demetska, P.M. itte, etc.).
During 2004 - 2008, large-scale epidemiological and clinical-statistical studies on the risk of development of occupational cancer among those working in various economic sectors of Ukraine were carried out in the Institute (AM Nahorna, D.V. Varyvonchyk, etc.).
In accordance with the Decision of the Scientific Council for Theoretical and Preventive Medicine under the Presidium of the Academy of Medical Sciences of Ukraine of July 17, 2008, a Special Scientific Laboratory of Epidemiology and Prevention of Occupational Cancer was organized in the Department of epidemiological studies (on January 1, 2009) (Head - Dr. Dr.med.sci. V. Varyvonchyk).
Following the ratification by Ukraine of the ILO Convention No. 139 "On the Control of the Danger Caused by Carcinogens and Agents in Production Conditions and Preventive Measures" (Law of Ukraine No. 1956-VI of 10.03.2010), there occurred a need in a long-term scientific support of implementation of measures on the control of occupational cancer at the state level, therefore, so, since January 1, 2011, a separate scientific unit - the Laboratory of Carcinogenic Danger and the Prevention of Occupational Cancer (headed by D. Med. ND) - was established in the SI “institute of Occupational Health named after Yu.I.Kundiyev of the NAMS of Ukraine" (Head- Dr.med. sci. D.V. Varyvonchyk).
Після ратифікації Україною Конвенції МОП №139 «Про боротьбу з небезпекою, спричинюваною канцерогенними речовинами й агентами у виробничих умовах, та заходи профілактики» (Закон України № 1956-VІ від 10.03.2010 р.), виникла необхідність тривалого наукового супроводу впровадження на державному рівні заходів боротьби з професійним раком, тому з 01.01.2011 р. в ДУ «ІМП імені Ю. І. Кундєіва НАМН» було створено відокремлений науковий підрозділ – лабораторію канцерогенної небезпеки та профілактики професійного раку (завідувач – д. мед. н. Д. В. Варивончик).
PURPOSE of the Activity – scientific support of the national system on preventing occupational cancer in Ukraine
1. Conducting scientific studies by the following directions:
– support of measures on the sanitary supervision, attestation of work places for assessment of the cancer danger in various types of economic activity;
- definition of epidemiological and medical-social regularities in morbidity of occupational cancer for the population;
- establishment of etiological factors, regularities of pathogenesis and clinical
course of occupational cancer;
- development of early diagnostic measures, substantiation of the expert criteria in establishment of occupational cancer;
– substantiation of measures on systemic prevention of occupational cancer.
1) The possibility of controlling the population carcinogenic risks of development of cancer and melanoma of the skin, the organ of vision among outdoor workers, based on the prediction of the exposure carcinogenic dose of ultraviolet radiation, based on the global space satellite observations, has been proved.
2) The etiological unity and pathogenetic differences in the occurrence of occupational bronchial and lung cancer in patients with pneumoconiosis and dust bronchitis have been proved, allowing to ground new approaches to the secondary prevention and early diagnostics in workers of the coal mining industry.
3) A polyethiologic theory on the origin of malignant melanoma has been developed, based on mechanisms of the hereditary predisposition and a combination of chemical, physical and biological carcinogenesis, allowing to revise the system of assessment of individual risks, prevention and early diagnostics of this pathology.
4) Work conditions and risks have been assessed; new approaches to diagnostics, treatment and prevention of multiple organ syndromic lesions have been developed in the manganese ore industry workers.
1) A scientific methodology for assessing carcinogenic risks in all sectors of Ukraine's economic activity has been developed, based on the data of the carcinogenic potential of agents and exposure levels.
2) National epidemiological monitoring of patients with occupational cancer is going on (since 1992 till present time).
3) Epidemiological monitoring of carcinogenic risks and oncological morbidity of asbestos cement workers in Ukraine has been started.
4) The epidemiological regularities of occurrence of occupational bronchial and lung cancer and hemoblastosis in workers of underground mining of uranium ores have been determined, being the basis for developing new approaches to prevention of cancer pathology among them.
5) Carcinogenic hazards have been identified and more effective preventive measures have been proposed for works with chemotherapeutic drugs in oncological practice.
6) The causes and risks of occupational infection with HIV / AIDS and tuberculosis in the field of health protection have been investigated, new directions of prevention of the said infectious diseases in the workplace have been developed.
7) The causes and risks of work-related cancer pathology among health workers are investigated.
1. Creation and information comparison of databases on working conditions and morbidity of workers on malignant neoplasms.
2. Assessment of oncological and epidemiological situations in populations and cohorts.
3. Epidemiological analysis of risk factors and cancer morbidity of the population and workers (descriptive, cohort study, case-control study).
4. Identification of carcinogenic hazards in the workplace (according to the IARC classification).
5. Estimation of individual and population carcinogenic risks of the population and workers (by the US EPA method).
6. Prognosis of cancer morbidity levels in the population and cohorts.
7. Development and assessment of the effectiveness of targeted screening programs for malignant neoplasms during medical examinations of the population and workers.
8. Development and evaluation of the effectiveness of multi-level prevention programs for malignant neoplasms.
9. Clinical and epidemiological examination and establishment of a link between a disease with a malignant neoplasm and work conditions.
10. Clinical and epidemiological assessment of the effectiveness in providing medical care to cancer patients.
Information as of 23.10.2017